Treatment

The effectiveness of the most commonly used antihel-minthics (i.e., albendazole and mebendazole) is strictly related to the amount of time that has elapsed since the individual acquired the infection: they are completely effective only when used in the early stages of infection. As a general rule, the later the treatment is prescribed, the higher the probability that the infected person will harbor viable larvae in their muscles for years, with possible persistent myalgia. Thus, as the time elapsed since infection increases, the doses of antihelminthics should be higher and they should be administered for longer periods of time.[7]

Mebendazole should be administered at a daily dose of 25 mg/kg/day, in 3-4 doses/day for 2 weeks. Albendazole should be administered at a daily dose of 20 mg/kg/day, in 3-4 doses/day for 2 weeks. For severe infections, treatment can be repeated after 5 days.[7]

Fig. 1 Multiplex PCR amplification of single larvae of Trichinella. Photograph of an ethidium bromide-stained 2.5% agarose gel under ultraviolet light illumination. The samples are as follows: L (ladder 50), sizes are in base pairs; lane 1, T. spiralis; lane 2, T. nativa; lane 3, T. britovi; lane 4, Trichinella T8; lane 5, Trichinella T9; lane 6, T. pseudospiralis (Palearctic isolate); lane 7, T. pseudospiralis (Nearctic isolate); lane 8, T. pseudospiralis (Tasmanian isolate); lane 9, T. murrelli; lane 10, Trichinella T6; lane 11, T. nelsoni; lane 12, T. papuae; lane 13, T. zimbabwensis.

Fig. 1 Multiplex PCR amplification of single larvae of Trichinella. Photograph of an ethidium bromide-stained 2.5% agarose gel under ultraviolet light illumination. The samples are as follows: L (ladder 50), sizes are in base pairs; lane 1, T. spiralis; lane 2, T. nativa; lane 3, T. britovi; lane 4, Trichinella T8; lane 5, Trichinella T9; lane 6, T. pseudospiralis (Palearctic isolate); lane 7, T. pseudospiralis (Nearctic isolate); lane 8, T. pseudospiralis (Tasmanian isolate); lane 9, T. murrelli; lane 10, Trichinella T6; lane 11, T. nelsoni; lane 12, T. papuae; lane 13, T. zimbabwensis.

Glucocorticosteroids (e.g., prednisolone 30-60 mg/day in multiple doses) should be administered together with the benzimidazole and never alone because they could increase the larval burden by delaying the expulsion of adult worms from the intestine.

Pregnant women should only be treated if the infection is severe and under the strict supervision of a physician. Only antihelminthics (e.g., pyrantel) that are poorly absorbed by the intestinal lumen should be used. These antihelminthics are affective only against intestinal worms and not against migrating larvae or larvae in the muscles.[7] Prednisolone can be administered at a dose of 20-30 mg/day, tapering the dose, particularly for women in the third trimester.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

Get My Free Ebook


Post a comment