Cholera is characterized by a severe watery diarrhea caused by toxigenic V. cholerae, which colonizes the small intestines and produces an enterotoxin, CT. Although production of CT encoded by the ctxAB genes is directly responsible for the manifestation of diarrhea, cholera pathogenesis relies on the synergistic action of a number of other genes, such as colonization TCP and outer membrane protein (ompU), and a regulatory protein, ToxR, which coregulates the expression of CT and TCP, and part of the CTX-genetic element comprising zonula occludens toxin (zot) and accessory cholera enterotoxin (ace), which are virulence factors and also play a role in the morphogenesis of the filamentous phage CTXO.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.