axis. In ovarian tumor, p53 status is a strong predictor of response to platinum-based chemotherapy. Patients whose tumors have p53 mutations show fewer chances to achieve a complete response following platinum-based regimens compared with patients without p53 mutations. Conversely, experimental and clinical data seem to show that paclitaxel enhances apoptosis through a p53-independent pathway. Such observations highlight the usefulness of p53 gene profiling as a form of cancer diagnosis and genotyping in defining the best therapeutic treatment for each patient.
Treatments depending on the p53 pathway require the scanning of the entire p53 gene and the identification of any type of mutation, not only in the p53 gene.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.