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axis.[5] In ovarian tumor, p53 status is a strong predictor of response to platinum-based chemotherapy. Patients whose tumors have p53 mutations show fewer chances to achieve a complete response following platinum-based regimens compared with patients without p53 mutations. Conversely, experimental and clinical data seem to show that paclitaxel enhances apoptosis through a p53-independent pathway. Such observations highlight the usefulness of p53 gene profiling as a form of cancer diagnosis and genotyping in defining the best therapeutic treatment for each patient.[6]

Treatments depending on the p53 pathway require the scanning of the entire p53 gene and the identification of any type of mutation, not only in the p53 gene.

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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