Immune Response

In 1997 Walker et al reported higher T lymphocyte counts, increased oxidative activity of leukocytes and lower concentrations of inflammatory mediators following VATS versus open thoracotomy for pulmonary lobectomies.32 Although open thoracotomy produced greater immune suppression, there was no difference in clinical outcome between the groups. However MaKinlay et al24 noted a trend toward greater disease-free survival rates in patients treated by VATS for pulmonary malignancies. The full impact of immune suppression of VATS for pulmonary malignancies has yet to be determined.15

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