The Ann Arbor staging system originally developed for HD is currently used for NHL patients as well. The pattern of disease spread in NHL is different from HD and prognostic variables for staging have been identified. The International Prognostic Index (IPI) incorporates age, LDH serum level, performance status, extranodal sites, and the Ann Arbor system for staging purposes. The IPI system effectively predicts survival for intermediate and low grade NHL. NHL is such a diverse group of lymphoid neoplasms with unique natural histories and patterns of presentation that a systematic approach cannot be established. NHL diagnosis is essentially similar to HD.
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