Natriuretic Peptides and their Receptors

Lincoln R. Potter

University of Minnesota, MinneapolisMinnesota, USA

Natriuretic peptides are an ancient family of hormones/para-crine factors that regulate blood pressure, cardiovascular homeostasis, and bone growth. The mammalian family consists of atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. All three peptides are derived from separate genes, but share a common 17-amino-acid disulfide ring that is required for biological activity. A family of three cell surface receptors mediates their cellular effects: two are receptor guanylyl cyclases, enzymes that catalyze the synthesis of the intracellular second messenger, cGMP, whereas one is a decoy receptor that lacks enzymatic activity. In this article, the structure, function, and regulation of each hormone and receptor are discussed.

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