Lincoln R. Potter
University of Minnesota, MinneapolisMinnesota, USA
Natriuretic peptides are an ancient family of hormones/para-crine factors that regulate blood pressure, cardiovascular homeostasis, and bone growth. The mammalian family consists of atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. All three peptides are derived from separate genes, but share a common 17-amino-acid disulfide ring that is required for biological activity. A family of three cell surface receptors mediates their cellular effects: two are receptor guanylyl cyclases, enzymes that catalyze the synthesis of the intracellular second messenger, cGMP, whereas one is a decoy receptor that lacks enzymatic activity. In this article, the structure, function, and regulation of each hormone and receptor are discussed.
Was this article helpful?
Never before revealed. Home Detox - Step By Step Guide To Dextoxify The Body. Has too much late night behavior and partying got you feeling bad about yourself? Are you trying to lose weight but nothing is happening? Maybe you are just sick of all of the toxins that are in the air you breathe, the water you drink and the foods you eat. If so, then you need to do something about it. If you find yourself feeling bad about your health, there are ways that you can help your body right at home.