Introduction

Farnesyltransferase and geranylgeranyltransferase inhibitors have remarkable potential for the treatment of cancer, cardiovascular disease, and a wide range of other disorders. The objective of this introductory chapter is to set the development of these prenylation inhibitors within the general context of contemporary drug discovery, covering the major drivers of unmet medical need, commercial imperatives, and intellectual challenge, and focusing on the issues surrounding development of signal transduction inhibitors in particular. The emphasis is on small molecule drugs, but much of the chapter is relevant to approaches with higher molecular weight agents, such as antibodies, other therapeutic proteins, antisense oligonucleotides, and gene therapy.

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Your Heart and Nutrition

Your Heart and Nutrition

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