A

synaptic cleft

cytoplasm

G-protein cytoplasm

G-protein

Figure 6.4. Molecular structure of the metabotropic 5-HT4 receptor. This seven-membrane spanning structure is typical of most metabotropic neurotransmitter receptors.

caudate nucleus globus pallidum coronal section white high s-ht3 area postnema tract us solltiirlui

■ LOW S-HT3 limbic system hippocampus ccrcbral cortex

hippocampus

Figure 6.5. Distribution of the 5-HT3 receptor. The 5-HT3 receptor subtype is a ligand gated ion channel that controls dopamine f, release. It is a common target of antiemetic therapy, as well as other psychoactive drugs. A high density of 5-HT3 receptors has p been identified in the human brainstem, particularly in the area postrema (the putatitive vomiting centre of the brain) and the r<

nucleus tractus solitarius. Lower levels of expression of the 5-HT3 receptor have been shown in the limbic system, hippocampus ^

and the cerebral cortex. k;

mid sagittal scction pre-fronlal cortex tsrubral «Jilex. hypothalamus

iir^ pOiUema hippocampus high s-ht3 area postnema tract us solltiirlui

■ LOW S-HT3 limbic system hippocampus ccrcbral cortex r caudate nucleus corpus btr ¡a tu m^ puta men globus pallidum mid sagittal scction pre-fronlal cortex iir^ pOiUema coronal section white tsrubral «Jilex. hypothalamus thalamus gland limbic system medulla oblongata ©CNSforUm.COm

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