No attempt will be made to give details of the experimental and clinical studies which have been surveyed in this text. I trust that the authors of these studies will forgive me for this deliberate omission, but my intention has been to create a readable text, not a detailed monograph, in which the flavour and excitement of the advances in psychopharmacology will encourage those interested to read further. With this in mind, a list of key monographs, review articles and textbooks is included merely as a guide for the reader. The choice of texts may seem idiosyncratic to some readers, but they include those which have appealed to the author because of their clarity, comprehensive nature or contribution to the advances in psychopharmacology.
Bazier, S. Psychotropic Drugs Directory. Salisbury: Quay Books, 2001.
Davis, K. L., Charney, D., Coyle, J. T. and Nemeroff, C. B. (Eds) Neuropsycho-
pharmacology - The Fifth Generation of Progress. New York: Raven Press, 2002. D'haenen, H. A. H., den Boer, J. A. and Willner, P. (Eds) Biological Psychiatry, Vols 1
and 2. Chichester: John Wiley & Sons, 2002. Feldman, R. S., Meyer, J. S. and Quenzer, L. F. Principles of Neuropsychopharmacology.
Sunderland, MA: Sinauer Associates Inc., 1997. Janicak P. G., Davis, J. M., Preskorn, S. H. and Ayd, F. J. Principles and Practice of Psychopharmacology (Third Edition). Philadelphia: Lippincott, Williams and Wilkins, 2001.
Kasper, S., den Boer, J. A. and Sitsen, A. J. M. (Eds). Handbook of Depression and
Anxiety (Second Edition). New York: Marcel Dekker, 2003. King, D. J. Seminars in Clinical Psychopharmacology (Second Edition). London: Gaskell, 2003.
Lopez-Ibor, J. J., Goebel, W., Maj, M. and Sartorius, N. Psychiatry as a Neuroscience.
Chichester: John Wiley & Sons, 2002. Schatzberg, A. F. and Nemeroff, C. B. Textbook of Psychopharmacology. Washington,
DC: American Psychiatric Press, 1998. Webster, R. A. (Ed.) Neurotransmitters, Drugs and Brain Function. Chichester: John Wiley & Sons, 2001.
490 FUNDAMENTALS OF PSYCHOPHARMACOLOGY
Chapter 1 - Functional Neuroanatomy of the Brain
Fitzgerald, M. J. T. and Folan-Curran, J. Clinical Neuroanatomy (Fourth Edition). Edinburgh: W. B. Saunders, 2002.
Chapter 2 - Basic Aspects of Neurotransmitter Function
Barbour, B. and Hausser, M. Intersynaptic diffusion of neurotransmitters. TINS 20 (1997): 377-384.
Conn, P. T. and Pin, J.-P. Pharmacology and functions of metabotropic glutamate receptors. Ann. Rev. Pharmacol. 37 (1997): 205-232.
Dingledine, R. The glutamate receptor ion channel. Pharmacol. Rev. 51 (1999): 7-61.
Kandel, E. R., Schwartz, J. H. and Jessell, T. M. Principles of Neural Science (Fourth Edition). Englewood Cliffs, NJ: Prentice-Hall, 2000.
Kerr, D. I. and Ong, J. GABA-B receptor. Pharmacol. Ther. 67 (1995): 187-246.
Langer, S. Z. 25 Years since the discovery of presynaptic receptors: present knowledge and future prospects. TIPS 18 (1997): 95-99.
Lindstrom, J. M. Nicotinic acetylcholine receptors in health and disease. Mol. Neurol. 15 (1997): 193-222.
Moss, S. T. and Smart, T. G. Constructing inhibitory synapses. Nat. Rev. Neurosci. 2 (2001): 240-250.
Nicoll, R. A. The coupling of neurotransmitter receptors to ion channels in the brain. Science 241 (1988): 545-551.
Povlock, S. L. and Amara, S. G. The structure and function of noradrenaline, dopamine and 5-hydroxytryptamine transporters. In: Neurotransmitter Transporters. Totowa, NJ: Humana Press, 1999, pp. 1-28.
Sautel, M. and Milligan, G. Molecular manipulation of G-protein coupled receptors: a new avenue into drug discovery. Curr. Opin. Med. Chem. 7 (2000): 889-894.
Shepherd, G. M. and Erulkar, S. D. Centenary of the synapse: from Sherrington to the molecular biology of the synapse and beyond. TINS 20 (1997): 385-392.
Soellner, T. and Rothman, J. E. Neurotransmission: harnessing fusion machinery at the synapse. TINS 17 (1994): 344-348.
Stanford, S. C. and Salman, P. Beta-adrenoceptors and resistance to stress: old problems and new possibilities. J. Psychopharmacol. 6 (1992): 15-19.
Wess, K. A. and Neve, R. L. (Eds) The Dopamine Receptors. Totowa, NJ: Humana Press, 1997.
Chapter 3 - Pharmacokinetic Aspects of Psychopharmacology
Bertilson, L. and Dahl, M. L. Polymorphic drug oxidation: relevance to the treatment of psychiatric disorders. CNS Drugs 5 (1996): 200-212.
Brosen, K. Are pharmacokinetic drug interactions with SSRIs an issue? Int. J. Psychopharmacol. 11 (Suppl. 1) (1996): 23-27.
Catterson, M. O. and Preskorn, S. H. Pharmacokinetics of selective serotonin reuptake inhibitors: clinical relevance. Pharmacol. Toxicol. 78 (1996): 203-228.
Fugh-Berman, A. Herb drug interactions. Lancet 355 (2000): 134-138.
Fuhr, U. Drug interactions with grapefruit juice: extent, probable mechanism and clinical relevance. Drug Safety 18 (1998): 251-272.
Horsmans, Y. Major cytochrome P450 families: implications in health and liver disease. Acta Gastro-Enterol. Belg. 15 (1997): 2-10.
Nemeroff, C. B., De Vane, C. L. and Pollock, B. G. Newer antidepressants and the cytochrome P450 system. Am J. Psychiat. 153 (1996): 311-320.
Stockley, I. H. Drug Interactions: A source book of adverse interactions, their mechanisms, clinical importance and management (Fifth Edition). London: Pharmaceutical Press, 1999.
Chapter 4 - Clinical Trials and their Importance in Assessing the Efficacy and Safety of Psychotropic Drugs
Healy, D. and Doogan, D. P. (Eds) Psychotropic Drug Development. London: Chapman and Hall Medical, 1996. Jick, H. Adverse drug reactions: the magnitude of the problem. J. Allergy Clin.
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Pharmacol. 27 (1987): 542-548. McDevitt, D. G. and MacDonald, T. M. Post-marketing drug surveillance - how far have we got? Quart. J. Med. 78 (1991): 1-3. Passamani, E. Clinical trials - are they ethical? N. Engl. J. Med. 324 (1991): 1589-1592. Temple, R. Trends in pharmaceutical development. Drug Inf. J. 27 (1993): 355-366.
Chapter 5 - Molecular Genetics and Psychopharmacology
Heilig, M. Antisense technology: prospects for treatment in neuropsychiatric disorders. CNS Drugs 1 (1994): 405-420.
Lerer, B. (Ed.) Pharmacogenetics of Psychotropic Drugs. Cambridge: Cambridge University Press, 2002.
Mallet, J. Catecholamines: from gene regulation to neuropsychiatric disorders. TIPS 17 (1996): 129-135.
Mueller, R. F. and Young, I. D. Emery's Elements of Medical Genetics (Seventh Edition). Edinburgh: Churchill Livingstone, 2001.
Stahl, S. M. New drug discovery in the post genomic era: from genomes to proteomics. J. Clin. Psychiat. 61 (2000): 894-895.
Wagner-Savill, K. and Kay, S. A. Circadian rhythm genetics: from flies to mice and humans. Nat. Genet. 26 (2000): 23-27.
Watson, S. T., Meng, F., Thompson, R. C. and Abil, H. The "chip" as a specific genetic tool. Biol. Psychiat. 48 (2000): 1147-1156.
Chapter 6 - Psychotropic Drugs that Modify the Serotonergic System
Aghajanian, G. K. and Marek, G. J. Serotonin and hallucinogens. Neuropsycho-
pharmacol. 21 (1999): 16S-23S. Barnes, N. M. and Sharp, T. A review of central serotonin receptors and their function. Neuropsychopharmacol. 13 (1999): 983-1152.
Baumgarten, H. G. and Goethert, M. (Eds) Serotoninergic neurons and 5-hydroxytryptamine receptors in the CNS. Handbook of Experimental Pharmacology, Vol. 129. Berlin: Springer-Verlag, 1997.
Gillman, P. K. The serotonin syndrome and its treatment. J. Psychopharmacol. 13 (1999): 100-109.
Heils, A., Mossner, R. and Lesch, K. P. The human serotonin transporter gene polymorphism - basic research and clinical implications. J. Neural. Trans. 104 (1997): 1005-1014.
Hoyer, D., Clarke, D. E. and Fozard, J. R. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46 (1994): 157-164.
Jacobs, B. L. and Fornal, C. A. Activation of serotonergic neurons in behaving animals. Neuropsychopharmacol. 21 (1999): 95-158.
Marshall, S. E., Bird, T. G. and Hart, K. Unified approach to the analysis of genetic variation in serotonergic pathways. Am. J. Med. Genet. 88 (1999): 621-627.
Naughton, M., Mulrooney, J. B. and Leonard, B. E. A review of the role of serotonin receptors in psychiatric disorders. Hum. Psychopharmacol. 15 (2000): 397-415.
Pinegro, G. and Blier, P. Autoregulation of serotonin neurons: role in antidepresant drug action. Pharmacol. Rev. 51 (1999): 533-591.
Uphouse, L. Multiple serotonin receptors: too many, not enough or just the right number. Neurosci. Biobehav. Rev. 21 (1997): 679-698.
Artigas, F., Perez, V. and Alvarez, E. Pindolol induces a rapid improvement of depressed patients treated with serotonin reuptake inhibitors. Arch. Gen. Psychiat. 51 (1994): 248-251.
Asberg, M., Traskman, L. and Thoren, P. 5HIAA in the CSF: a biological chemical suicide predictor. Arch. Gen. Psychiat. 33 (1976): 1193-1197.
Benedetti, F. Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficiency of fluvoxamine. Mol. Psychiat. 3 (1998): 508-511.
Cassidy, S. L. and Henry, J. A. Fatal toxicity of antidepressant drugs in overdose. Br. Med. J. 295 (1987): 1021-1024.
Davis, L. L., Yonkers, K. A., Trivedi, M., Kramwer, G. L. and Petty, F. The mechanism of action of SSRIs: a new hypothesis. In: Selective Serotonin Reuptake Inhibitors: Past, Present and Future, Stanford, S. C. (Ed.). Austin, TX: R. G. Lander, 1999, pp. 171-185.
Farmer, R. D. T. Suicide and poisons. Hum. Psychopharmacol. 9 (Suppl. 1) (1994): S11-S18.
Grasby, P. M. Imaging strategies in depression. J. Psychopharmacol. 13 (1999): 346351.
Kasper, S., den Boer, J. A. and Sitsen, A. J. M. (Eds) Handbook of Depression and Anxiety (Second Edition). New York: Marcel Dekker, 2003.
Ordway, G. A. Pathophysiology of the locus caeruleus in suicide. Ann. NY Acad. Sci. 836 (1997): 233-252.
Schildkraut, J. J. The catecholamine hypothesis of affective disorders: review of the supporting evidence. Am. J. Psychiat. 122 (1965): 509-522.
Spina, E. and Perucca, E. Newer and older antidepressants: a comparative review of their drug interactions. CNS Drugs 2 (1994): 479-490.
Yamada, M. and Higuchi, T. Functional genomics and depression research: beyond the monoamine hypothesis. Eur. Neuropsychopharmacol. 12 (2002): 235-244.
Belmaker, R. H. How does lithium work in manic depression? Clinical and psychological correlates of the inositol theory. Ann. Rev. Med. 47 (1996): 47-60.
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Keck, P. E. and McElroy, S. L. Outcome of the pharmacological treatment of bipolar disorder. J. Clin. Psychopharmacol. 16 (Suppl.) (1996): 15-23.
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Brunello, N. New insights into the biology of schizophrenia through the mechanism of action of clozapine. Neuropsychopharmacol. 13 (1995): 177-188.
Conley, R. R., Tamminga, C. A. and Beasley, C. Olanzapine versus chlorpromazine in therapy-refractory schizophrenia. Schizophren. Res. 24 (1997): 190-202.
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Chapter 12 - Drug Treatment of the Epilepsies
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Chapter 13 - Drug Treatment of Parkinson's Disease
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Chapter 14 - Alzheimer's Disease and Stroke: Possible Biochemical Causes and Treatment Strategies
Adams, M. P. Treating ischaemic stroke as an emergency. Arch. Neurol. 55 (1998): 457-461.
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Chapter 15 - Psychopharmacology of Drugs of Abuse
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Chapter 18 - The Inter-relationship Between Psychopharmacology and Psychoneuroimmunology
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Chapter 19 - Endocoids and their Importance in Psychopharmacology
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