Figure 11.6. Schematic diagram of the possible sites of action of drugs that modify dopaminergic function in striatal and other non-mesocortical regions of the mammalian brain. PCM=protein;0-methyltransferase, which catalyses the transfer of methyl groups from S-adenosylmethionine to the calmodulin-dependent regulatory protein and may regulate calcium-calmodulin dependent transmitter synthesis and release. (—)=inhibition; (+)=stimulation; DA=dopamine. Sites of action of drugs are underlined.

SKF3&3SJ -

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