Effects of neuroleptics on dopaminergic and other neurotransmitter systems

Because of the discovery that all neuroleptics in clinical use are dopamine receptor antagonists, and that an abnormality in the dopaminergic system might underlie the pathology of the condition, the action of neuroleptics on the dopaminergic system has been extensively studied over the past two decades. Four major anatomical divisions of the dopaminergic system have been described:

Table 11.3. Key post-mortem findings concerning the major transmitter systems implicated in schizophrenia

Transmitter

Main post-mortem findings

Other supporting evidence a ยง

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