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Figure 6.6. Distribution of 5-HT4 receptors. The 5-HT4 receptor subtype is coupled to a G protein that stimulates the intracellular messenger adenylate cyclase that, in turn, regulates neurotransmission. In the human brain, a high density of 5-HT4 receptors has been identified in the striatonigral system, notably in the caudate nucleus, lenticular nucleus (putamen and globus pallidus) and the substantia nigra. Lower levels of expression of the 5-HT4 receptor have been shown in the hippocampus and ^

the frontal cortex. fe coronal section rcaudate nucleus corpus striatum^! putamen olfactory tubercle globus pallid us nucleus acturribens_ amygdala

HIGH 5-HT6 olfactory tubercle nucleus accumbens dentate gyrus hippocampus

L0W5-HT6 cerebellum amygdala

| S-HT7 thalamus coronal section rcaudate nucleus corpus striatum^! putamen

cerebral cortex hypothalamus

_ h substantia nigra mid-sagittal section cerebral cortex hypothalamus

_ h cerebellum substantia nigra pre-frontal cortex mid-sagittal section pre-frontal cortex

cerebellum

■ limbic system pituitary gland rostral raphe nuclei midbrain

■ limbic system pituitary gland rostral raphe nuclei midbrain

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