H

r1 tn

Figure 6.5. Distribution of the 5-HT3 receptor. The 5-HT3 receptor subtype is a ligand gated ion channel that controls dopamine f, release. It is a common target of antiemetic therapy, as well as other psychoactive drugs. A high density of 5-HT3 receptors has p been identified in the human brainstem, particularly in the area postrema (the putatitive vomiting centre of the brain) and the r<

nucleus tractus solitarius. Lower levels of expression of the 5-HT3 receptor have been shown in the limbic system, hippocampus ^

and the cerebral cortex. k;

lenticular

"i cauda┬╗ nucleus puta men coronal section nucleus ^globus pallidas amygdala

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