Mechanism of action of neuroleptics

Laborit in the early 1950s is credited with the observation that chlorpromazine had a ''calming'' effect in disturbed schizophrenic patients and since that time psychopharmacologists have sought to explain the mechanism of action of neuroleptic drugs. Carlsson and Linquist in 1963 demonstrated a link between the therapeutic effects of the phenothiazine neuroleptics and an inhibition of dopamine receptor function. This led to

Table 11.4. New families of dopamine receptor subtypes


Relevance for antipsychotic drug action

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