Transient urinary morbidity related to radiation-induced urethritis or prostatitis represents the most common side effect after prostate brachytherapy. The symptoms include urinary frequency, urinary urgency, and dysuria. Because of the varying definitions of toxicity reported in the literature, it is difficult to quantify the true risks of treatment-related toxicities after seed implantation. Many reports have not described toxicity outcomes using actuarial methods, and in some studies only severe toxicity is reported while more moderate complications (grade 2) are not reported. In addition, various implantation techniques, seed activity, and source distribution patterns used by different centers have contributed to the wide range of side-effect profiles reported after prostate brachytherapy.
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