Respiratory Organ

A study of cultured lung rudiments during the Space Shuttle STS-54 mission suggested that development and differentiation of mammalian lung continues in microgravity (Spooner et al. 1994). Parathyroid Hormone-related Protein (PTHrP) has been shown to be essential for the development and homeostasis of lung. It is a highly evolutionarily conserved stretchregulated gene that is necessary for the embryonic transition from branching morphogenesis to alveolization of the lung. The differentiation of the alveolar epithelium and the surrounding mesoderm are critical for preparing the

Figure 5-09. Bone mineralization during mouse embryogenesis. Photograph of a 16-day-old bone cultured for 4 days in space in microgravity (D+4 days, 0 G) or in an onboard 1-g centrifuge (D+4 days; 1 G Flight). The photograph on the left shows a bone rudiment immediately after dissection (D). Note that in microgravity the center of the bone is less mineralized (dark area) than in 1 g. Adapted from Velthuijzen

Figure 5-09. Bone mineralization during mouse embryogenesis. Photograph of a 16-day-old bone cultured for 4 days in space in microgravity (D+4 days, 0 G) or in an onboard 1-g centrifuge (D+4 days; 1 G Flight). The photograph on the left shows a bone rudiment immediately after dissection (D). Note that in microgravity the center of the bone is less mineralized (dark area) than in 1 g. Adapted from Velthuijzen

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