Neuroendocrine Syndromes

Prader-Willi syndrome is a neuroendocrine disorder with chromosomal abnormalities (characterized by deletion of the proximal part of the long arm of chromosome 15 among other abnormalities) first described by Prader, Labhart, and Willi in 1956.40 The diagnostic features are those of obesity, short stature, and developmental delay, with the child presenting with profound muscular hypotonia, swallowing difficulties, and hypogonadism. A single case has been reported of a 10-day-old neonate with bilateral SDH of the posterior falx with associated extradural hemorrhage, which was hypothesized to be caused by a genetically related abnormality of homeostasis, although the specific homeostatic abnormality was not stated.41 The infant had been delivered by cesarean section following breech presentation, although these delivery related mechanisms were excluded as the cause of the SDH.

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