An Overview on Bioreactor Design Prototyping and Process Control for Reproducible Three Dimensional Tissue Culture

Ralf Pörtner and Christoph Giese

2.1 Introduction 53

2.2 Important Aspects for Bioreactor Design 55

2.3 Culture Systems and Bioreactors Used in Tissue Engineering 57

2.4 The Operation of Bioreactors 59

2.5 3D Systems Used for Drug Testing 62

2.6 Modeling of Bioreactor Systems for Tissue Engineering 62

2.7 The Artificial Immune System 65

2.7.1 Matrices 68

2.7.2 Microenvironment 68

2.7.3 Monitoring 68

2.8 Conclusions 69 References 70

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