Intelligent Biomaterials and Scaffolds for Tissue Engineering

Currently, a broad range of synthetic polymers are being used for scaffolding, including poly(e-caprolactone) (PCL), poly(i-lactide-co-e-caprolactone) (P(LLA-CL)), polyglycolic acid (PGA), polylactic acid (PLA), or copolymer poly (lactidic-co-glycolic) (PLGA) [1—4], as well as natural biomaterials such as alginate, elastin, collagen, or gelatin [5-9]. Ideally, all scaffold materials should be nontoxic, biocompatible, biodegradable, and nonimmunogenic. Moreover, for use in vivo, scaffolds should - with only few exceptions such as cartilage and cornea - be able to induce angiogenesis to facilitate blood supply to, and waste removal from, the newly formed tissues. The "intelligence" of a biomaterial and the ensuing scaffolds can be gauged from its competence to induce and maintain organ-specific differentiation and function of the cells growing in/on them and generating tissue-like constructs.

0 0

Post a comment