Supporting matrices for the CCS need to be perfusable, cell-adhesive, and cell-migrational. In contrast to biohybrid implant technology (e.g., cartilage), biodegradability is irrelevant, but cell proliferation and the growth of organoids is necessary. Matrix sheets of nonwoven fibers (polyamides), hygrogels (peptides, agaroses, alginates, fibrin) and sponges (collagens) are particularly suitable for this purpose. Matrix performance is defined by the composition and structural properties on nanometer and micrometer scales.

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