R

radiometric cellular assays 136 f. Ran GTPase 184 rapid screening 139 Rb-pathway 181

REACH see Registration, Evaluation and Authorization of Chemicals reactogenicity 165 real-time conditions 87 receptor binding assays 136 receptor tyrosine kinase (RTK) 143 recombinant vectors 155 recombination 187 ff.

- cassette 187 ff.

- consecutive 187 recording techniques 93

- cardiomyocytes 94

- extracellular 93

- intracellular 93 redifferentiation 215 reference materials 244 reference standards 232

- biological 232

- international 232 Registration, Evaluation and

Authorization of Chemicals (REACH) 205, 261 regulatory safety testing 257 reporter gene assays 137 reporter gene-based tests 214 reproducibility 132 reproductive toxicity 107 reproductive toxicology 213 ff. reprogramming 219 respiratory diseases 22 respiratory infections 157 respiratory syncytial virus 155 respiratory system 105 respiratory tract 105 retinal pigment epithelial cells 180 retroviral gene transfer 186 retroviruses 190 risk assessment 234 risk-management 275 RNA replicons 156 RNA silencing (siRNA) 211 ff. Ro 24-7429 191

roadside airborne particulates 112 robustness 135 3Rs 231, 251

RTK see receptor tyrosine kinase s safety 153

- testing 252

- toxicology 214 scaffold porosity 12 ff. scaffolds 11 ff., 184

- biodegradable 12 ff.

- bioerodible 12 ff.

- cell seeding 56

- electrospun 8

scaffolds for tissue engineering 7 ff.

- fabrication 7 ff.

scintillation proximity 137 second messenger assays 138 selection marker 188 semiconductor 91

- coupling electroactive proteins 91

- membrane-based 91 Semliki Forest virus (SFV) 156 senescence 180

SFV see Semliki Forest virus shuttle vector 186 signal shift 132

signal transduction pathways 137 signaling pathways 143 signaling proteins 143 silencing technologies 208 silicon nitride membranes 36 ff. Sindbis virus (SINV) 156 single cell analysis 245 SINV see Sindbis virus SiRNA see RNA silencing siRNA see small interfering RNA SIS see small intestinal submucosa site-specific recombinases 186

- Flp 186 skin 274

skin corrosivity 244 skin irritation test 261 skin sensitization 244 small interfering RNA (siRNA) 182 small intestinal submucosa (SIS) 5 small T antigen 181 smooth muscle cells 18 socio-ethical environment 280 SOD see superoxide dismutase soft-lithography 82 solvent tolerance 131 somatic cells 180 somatic stem cell niches 277, 279 spermatogonial stem cells (SSC) 179

SSC see spermatogonial stem cells standard 134

-blank control 134

- positive control 134 standard deviation 135 standardization 232, 237 ff. static culture conditions 18 stem cells 180, 278

- adult 278

- derived 278

- differentiation 279

- models 221

- prenatal 278

- technologies 273 sterility testing 239 stroke models 205 submerged exposure technique

sub-organe structures 274 sub-organoid structures 275 substrate-integrated electrodes 93 superoxide dismutase (SOD) 221 surrogate biomarker 208 ff. SV40 large T antigen 181 ff. synthetic metals 4 synthetic organs 167 synthetic polymers 4 ff., 8

- poly(L-lactide-co-e-caprolactone (LLA-CL) 4 ff.

- polyglycolic acid (PGA) 4 ff.

- polylactic acid (PLA) 4

- poly(lacitidic-co-glycolic acid (PLGA) 4 ff.

systemic toxicology 213 systems biology 218 ff., 271, 281

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