T

target oncology 144 target validation 80, 211 targets 127 Tat inhibitor 191

- Ro24-7429 191 Tat proteins 190 T cells 155, 191

- antigen-specific 155 T-cell activation 68 T-cell assay 160

- antigen-specific 160

- enzyme-linked immunnospot assay 160

- intracellular cytokine staining 160

- limiting dilution assay 160 T-cell cytotoxicity 163 f.

- chromium release assay 163

- flow cytometric assays 164

- Lysispot assay 163 ff. T-cell responses 153, 158, 165 telomerase 180 ff. telomeres 180

temperatur-dependent inactivation 184

TER see transcellular electric resistance tert gene 180

- ectopic expression 180

- endothelial cells 190

- fibroblasts 180

- keratinocytes 190

- retinal pigment epithelial cells 180

TGF-P 36

thermoreversible gels 21 three-dimensional spheroids 146 thymic organoids 168 thyroid epithelium 184 tight junctions 28, 273 tissue banks 233 f. tissue-based assays 243, 277

- guidelines for validation 243 ff.

- parameters 277 tissue-based impedimetric HTS 80 tissue-based sensor 88 ff.

tissue culture 237

- conditions 237

- differentiation state 237

- identity 237

- models 259

- validity 237

- vitality 237

tissue engineering 16 ff., 21 ff.,

36 ff., 53 tissue equivalents 3 ff. tissue models 277

- parameters 277 tissue-tracking system 234 toponome 80

toxic potency 110 toxicity endpoints 116 toxicity prediction 110 toxicity testing 205 ff. toxicology 105 ff., 178 trans-activator 193 transcellular electric resistance (TER) 89

transcellular permeability 32

- active 32

- passive 32 transcriptase activity 180 transcription factor beta-catenin 145 transcription factors 186 transformation 179 ff. transgenic animal models 211 transgenic mice 182

transient transfection 129 ff.

- adenoviruses 130

- calcium phosphate 130

- Semliki Forest virus 130 transwell culture systems 34 transwell cultures 113 ff. TRF1 180

TRF2 180 tumor cell lines 179 tumor spheroids 88

v vaccination schedules 165 vaccine efficacy 167 vaccine immunogenicity 167 vaccine testing 168 vaccines 153

- adjuvant effects 153

- complex 154

- efficacy 153

- hepatitis B virus 153

- inactivated 154

- live-attenuated 153

- potency 154

- preventive 153

- prophylactic 153 -recombinant viral vector 155

- safety 153

- therapeutic 154

- viral 154 vaccinia virus 155 ff. validated potency assays 155 validation 178, 211 ff., 220, 243 ff.,

358 ff.

- Amden workshop 258

- cell culture models 259

- guidelines 242

- in-vitro models 259

- in-vitro tests 259

- photoirridation test 260

- phototoxicity test 260 ff.

- studies 244

- tissue culture models 259 variability 135

vector vaccine DNA 155 Venezuelan equine encephalitis virus

(VEE) 156 Vero cells 240

vesicular stomatitis virus (VSV) 159 vimentin 182 viral isolates 192 viral promoters 185 ff.

- immediate early hCMV 185

- Rous sarcoma virus (RSV) 185 virus replication 155 virus-specific CTL 163 viruses 238 ff.

VOCs see volatile organic compounds volatile compounds 113 volatile organic compounds (VOCs) 114

VSV see vesicular stomatitis virus

WCPF see whole cell fingerprinting system whole cell fingerprinting system (WCPF) 80

Zentralstelle zur Erfassung und Bewertung von Ersatz- und Ergänzungsmethoden zum Tierversuch (ZEBET) 251 zidovudine 193

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