The Definition of High Content Screening

The term "high-content screening" (HCS) describes the analysis of drug activities in cell-based assays. It is a technology platform designed to define the temporal and spatial activities of genes, proteins, and other cellular constituents in living cells [82]. The measured events can include general effects (e.g., cellular morphology, apoptosis, migration), metabolic stimulation or inhibition, and specific effects on discrete target proteins. From a biology-orientated perspective, the term "phenotypic screening" is also often used to describe complex cell-based compound screening [83]. HCS is not a novel technique, but combines cellular manipulation, data acquisition and data processing within an integrated process.

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