Contents

Preface v

Contributors xi

1 • Animal Models of Folate-Related Neural Tube Defects 1

Nicholas D. E. Greene and Andrew J. Copp

2 • Genetic Variation in Folate Metabolism: Impact on Development 27

Rima Rozen

3 • Folate Deficiency and the Molecular Determinants of Chromosome Instability: Possible Link to Meiotic

Nondisjunction and Down Syndrome 43

S. Jill James and Charlotte A. Hobbs

4 • Folic Acid, Vitamin B12, and Genomic Stability of Human

Cells 71

Michael Fenech

5 • Molecular Genetics of Folate Metabolism 91

Manuela Födinger, Sonja Skoupy, and Gere Sunder-Plassmann

6 • Folate Receptor-a: An Update 117

Barton A. Kamen

7 • Folate, Homocysteine, and Neural Tube Defects 137

8 • Folic Acid and Homocysteine as Risk Factors for Neural

Tube Defects 165

Robert C. Barber, Janee van Waes, Edward J. Lammer, Gary M. Shaw, Thomas H. Rosenquist, and Richard H. Finnell

9 • Developmental Toxicants Potentially Acting via Folate

Perturbation 183

Deborah K. Hansen

10 • Brain Development and Choline, the Other Methyl Donor... 205

Steven H. Zeisel

11 • Nutrient Interactions Between Folate and Zinc or Copper:

Their Possible Implications to Pregnancy Outcome 219

Tsunenobu Tamura

12 • Regulation of Folate Metabolism by Iron 241

A. Katherine Herbig and Patrick J. Stover

13 • A Differential Role for Folate in Developmental Disorders,

Vascular Disease, and Other Clinical Conditions:

The Importance of Folate Status and Genotype 263

Mark Lucock and Zoe Yates

14 • Vascular Disease in Women: Folate and Homocysteine 299

15 • Folate, Homocysteine, and Cardiovascular Disease 329

Jayne V. Woodside and Ian S. Young

Index 345

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