H

Heat exposure, maternal, NTD, 16-17 HIV integrase, 79 Homocysteine, 299-301, child, 150-153

C677T gene mutation, 334-336 DNA damage, 77-78 early miscarriage, 308-309 elevated serum concentrations, 244

embryo, 148-149 estrogen, 305-307 fetus, 150 folate, 332-334 folic acid, 166 genetic factors, 334-336 menopausal transition, 305-308 menstrual cycle, 303-304 metabolism, 300-301, 331-332, metabolic pathways, 72 pathway, 5 NTD, 14-15, 144-149

OVD, 279-282 preeclampsia, 310-312 endothelial dysfunction, 311-312 pro-inflammatory effect, 338 remethylation, 242-244, 280 trophoblast, 149 vascular disease, 118, 302,

329-331 vascular toxicity, mechanisms, 336-338 Homocystinuria, 30 Howell-Jolly bodies, megaloblastic anemia, 73-74 HPV, 79

Human models, NTD, problems, 2 Human papilloma virus (HPV), 79 Hungarians,

Down's syndrome, 58 folic acid, 165 NTD, 143 Hydrocephalus, 185 Hyperchromocysteinemia, 35, C677T gene mutation, 315 fasting, 318 gender difference, 299 miscarriage, 309 oral contraceptives, 304-305 pregnancy,

677C->T mutation, 32 treatment, 317-318 unexplained pregnancy loss, 154 Hypovolemic shock, 312

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