I

1. Dihydrofolate reductase

2. Thymidilate synthase

3. Phosphoribosylglycimamide transformylase

4. Amiitocarboxamide ribotide transformylase

5. 10-Formyltetrahydrofolate dehydrogenase

6. lO-Formyltetrahydrofolate synthase

7. Methionyl t-RNA formyltransferase

8. 5,10-Methenyltctrahydrofolate cyclohydrolase

9. Dimethylgiycine dehydrogenase

10. Sarcosine dehydrogenase

11. Glycine cleavage system (forward reaction only)

12. Serinehydroxymethyl transferase

13. Serinehydroxy methyl transferase (minor reaction)

14. 5,10-Methenyltctrahydrofolate synthetase

15. Formiminotetrahydrofolate cyclodeaminase

16. Glutamate formiminotransferase

17. Methonine synthase

18. 5,10-Methylenetetrahydrofolate reductase

19. 5,10-Methylenetetrahydrofolate dehydrogenase 20* Folylpolyglutamate synthase (HjPteGhij is major substrate)

21. Gamma-glutamvl hydrolase (folylpolyglutamates converted to monoglutaniates)

22. Methionine adenosy(transferase

23. Methyltransferase reactions DNA ttlCthVliltiOIl

24. Glycine N-methy(transferase ^

25. S-adenosylhomocj'steine hydrolase 311(1 CdJlCCF "V"""^

26. Cysthathionine synthase . ^ ^

27. Methionine syhthase reductase > J\ /

Serine-

CpG methylation of DNA affecting gene expression x

SAM activation

-Down's syndrome -Birth defects -Complications of pregnancy -Cancer

-Vascular disease

18. Two common SNPs of the gene coding for this enzyme have been described, and may be clinically important:

0 0

Post a comment