N

Native folate, structure, 264-265 Native folate coenzymes, detection, 272

Neural tube closure, folate, 173-177 Neural tube defects (NTD), 273-279, animal models, 1-19, genetic background effects, 12 Axd mutant mice, 3-4 caudal, methionine, 4 copper deficiency, 228-230 cranial,

Cart1 knockout mice, 6, 7 677C->T mutation, 31-32 disabling malformation, 137 environmental factors, 137-138 environmental models, 13-19 folate, 221, studies, 141-144 folate cycle antagonists, 15-16 folate cycle metabolites, 14-15 folate deficiency, 13-14 folate metabolism, 170-173 folate-preventable,

Axd mutant mice, 3-4 folate-sensitive, risk, 167-173 genetic factors, 137-138 genetic models, complex, 9-10 folate-insensitive, 12-13 folate metabolism, 3-5 homocysteine, 144-149 human models, problems, 2 MTRR gene polymorphisms, 99 nutrition, 138-144 open spinal,

Axd mutant mice, 3 risk factors, 165-177

spinal, curly tail mice, 10 VPA, 17-18 Neutrophils, hypersegmentation, 250 NF1 mutations, splotch mutant mice, 10-11 NF1/splotch double mutants, 11 Nitrous oxide, 191-192, methionine synthase, 16 NMDAR, 166-167 N-methyl-D-aspartate type glutamate receptor (NMDAR), 166-167 NTD, see Neural tube defects Nutrition, NTD, 138-144

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