S

S-adenosylhomocysteine (SAH), 118

S-adenosylmethionine (SAM), 43, 118,

C677T polymorphism, 286-287 SAH, 118 SAM, 43, 118,

C677T polymorphism, 286-287 Schisis,

C677T polymorphism, 148 folic acid, 153 Schizophrenia,

677C->T mutation, 33-34 Serine hydroxymethyltransferase

(SHMT), 104-106, 246-252 Serine hydroxymethyltransferase1 (SHMT1), 104-106, polymorphisms, 106 Serine hydroxymethyltransferase2 (SHMT2),104-106, 246, gene product cytosolic serine hydroxymethyltrans-ferase, 105 gene product mitochondrial serine hydroxymethyl-transferase, 105 polymorphisms, 106 Serine hydroxymethyltransferase (SHMT) enzyme, 246, 277

SHMT, 104-106, 246-252 SHMT1, 104-106, polymorphisms, 106 SHMT2, 104-106, 246, gene product cytosolic serine hydroxymethyltransferase, 105

gene product mitochondrial serine hydroxymethyl-transferase, 105 polymorphisms, 106 SHMT enzyme, 246, 277 Single-nucleotide polymorphisms

(SNPs), 263 SLC19A1 gene, 100-101, gene product human folate transporter, 100 polymorphisms, 100-101, allele frequency, 101 disease associations, 101 metabolic effects, 101 rare mutations, 101 Smokers, blood folate, chromosome aberrations, 75

buccal mucosal folate, 75-76 MTR gene polymorphisms, 96 pregnancy, 188 SNPs, 263 South Wales, NTD, 137 Spain, pregnancy,

677C->T mutation, 32-33 Spina bifida, 137, 168, 273, double mutant mice, 9-10 homocysteine, 150-151 MTRR gene polymorphisms, 99

VPA, 18 Spinal neural tube defects, curly tail mice, 10, 12-13 splotch mutant mice, 10 Splenectomy, erythrocytes, micronuclei, 75 Splotch mutant mice, cranial neural tube defects, 9 NF1 mutations, 10-11 NTD, 7-9, methionine, 15 spinal NTD, 10 Spontaneous abortion, 219, Down's syndrome, 50-51 Staurosporine, 123 Sulfasalazine, 185

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