The association of secretion of human chorionic gonadotropin with prostate cancer has been reported in one case. Broder et al. have analyzed prospectively 16 patients with stage D adenocarcinoma for the presence of human placental lactogen (hPL), placental alkaline phosphatase (PAP), and human chorionic gonadotropin (hCG). Ectopic production of hCG was found in one of the 16 cases. Serial serum hCG levels in that patient mirrored his course more reliably than concomitant acid phosphatase levels. Serum estradiol, testosterone, the hCG-alpha subunit, hPL, and PAP were not elevated. There was a minimal elevation of serum follicle-stimulating hormone (FSH). There were no elevations of the other placental proteins in ten evaluable cases. A retrospective evaluation of serum bank specimens from 47 patients with prostatic carcinoma revealed no elevation of the placental proteins hPL, hCG-beta, and hCG-alpha. In this peculiar case, the ectopic origin of the hormone secretion was not documented with biochemical testing on the prostate tumor for the presence of hCG (Broder et al. 1977).
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