1. No atypia. Endometrial hyperplasia without atypia is treated with medroxyprogesterone acetate (MPA) 10 mg daily for 12 to 14 days each month for three to six months.
2. With atypia. Endometrial hyperplasia with atypia on endometrial biopsy is further evaluated by hysteroscopy with dilatation and curettage. If the diagnosis remains unchanged (eg, no coexistent adenocarcinoma), treatment with continuous oral megestrol 40 mg two to four times per day is initiated. Hysterectomy is an alternative for women who are not planning future pregnancy.
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