A

Phosphatidylethanolamine molecular species

Figure 6 Dietary lipid and the composition of human erythrocyte phosphatidylethanolamine. Erythrocyte PE species were analyzed from six volunteers before and after consumption of fish oil containing 9g eicosapentaenoic acid (22:5n-3) and 6g docosahaexenoic acid (22:6n-3) per day for 4 weeks. Results are expressed as mean ± SEM; *p < 0.05. (From Knapp HR, Hullin F and Salem N Jr (1994) Asymmetric incorporation of dietary n-3 fatty acids into membrane aminophospholipids of human erythrocytes. Journal of Lipid Research 35: 1283-1291.)

n-3 fatty acids was variable, and the extent of such changes was modest. This comparison illustrates a general observation that although manipulation of cultured cell phospholipid compositions by medium lipid supplementation is relatively easy, phospholi-pid compositions of similar cell types in vivo are considerably more resistant to dietary manipulation.

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