The vitamin (L-ascorbic acid) linked with scurvy is known to be a cofactor for two enzymes that take part in the biosynthesis of collagen, the major connective tissue protein; the formation of hydroxypro-line and hydroxylysine residues as catalyzed by prolyl hydroxylase and lysyl hydroxylase enzymes, respectively (Figure 8). Collagen is an essential component of the extracellular matrix. As a cofactor for dopamine-^-monooxygenase, L-ascorbic acid is also required for the synthesis of adrenaline (epinephr-ine) and noradrenaline (epinephrine) in the adrenal medulla. Another important noncofactor role of L-ascorbate is as an antioxidant in cells and blood.
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