Inactive cAMP-dependent protein kinase

Inactive protein phosphatase inhibitor 1


Krebs cycle

Krebs cycle

" Citrate

_ Active cAMP-dependent protein kinase

Acetyl-CoA carboxylase

" Citrate


Active protein phosphatase inhibitor 1

Inactive hormone-sensitive lipase

Active hormone-sensitive lipase

Malonyl-CoA +

Fatty acids

Triacylglycerol (+)

Glycerol Fatty acids

Figure 5 Lipolysis is stimulated by the action of glucagon, ACTH, and adrenaline. This effect is mediated by cyclic AMP-dependent protein kinase.

Death will occur when there is a failure to replenish fuel stores and insufficient available energy to maintain essential bodily functions. Because fat is the predominant source of energy, the time until death in uncomplicated fasting will depend on the size of the prefasting fat stores. In a normal adult, fat stores will be sufficient to sustain life for approximately 60-70 days. The extent of protein loss is also linked to survival. A loss of more than half of the lean body mass compartment (approximately half of total body protein) is predictive of death.

See also: Amino Acids: Metabolism. Carbohydrates:

Regulation of Metabolism. Energy: Metabolism; Requirements. Fatty Acids: Metabolism. Glucose: Chemistry and Dietary Sources; Metabolism and Maintenance of Blood Glucose Level. Lipids: Chemistry and Classification. Protein: Digestion and Bioavailability.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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