Biosynthesis and Metabolism

The biosynthesis and metabolism of homocysteine is presented in Figure 1. The ultimate source of homo-cysteine is dietary methionine. Methionine is first activated by addition of an adenosyl group (from ATP) to form S-adenosylmethionine (SAM). SAM is an important intermediate known as the universal methyl donor for its role as the methylating agent in a variety of essential reactions, including those involving DNA, RNA, proteins, membrane phospholipids,

Table 1 Structures and forms of homocysteine and related amino acids

Structures of homocysteine and related amino acids

Forms of homocysteine found in blood

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