Owing to the fact that damage to the developing brain is the most severe consequence of iodine deficiency, women of child-bearing age and children are the first priorities for receiving iodized oil. Recommendations are to give a single dose of 460 mg of iodine to all females below the age of 40 years. A single annual dose of 240 mg of iodine appears to be adequate for children. Larger doses do not necessarily provide longer protection because of increased urinary loss after administration. It is possible that smaller more frequent doses may be more effective, although this issue requires further study. Evidence from studies using 200-500 mg of iodized oil suggests that the protective effect lasts for between 6 months and 2 years.

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