Ep1ep4 Ip

BLT1, BLT2 CysLT1, CysLT2

Most cell types

Endothelial cells

Platelets Monocytes Mast cells

Monocytes Macrophages Uterine cells Epithelial cells Neutrophils Monocytes Macrophages Eosinophils Mast cells Eosinophils Mast cells Macrophages Smooth muscle cells

Potent vasodilator

Stimulates bone and cartilage resorption

Increases microvascular permeability

Mediator of febrile responses


Potent vasodilator

Inhibits platelet aggregation

Potent vasoconstrictor and inducer of platelet aggregation Vasodilator

Inhibits platelet aggregation

Potent vasoconstrictor and bronchoconstrictor

Myometrial and smooth muscle cell contraction

Potent neutrophil chemotactic and chemokinetic agent Induces leucocyte adhesion

Induces release of reactive oxygen species and hydrolytic enzymes by neutrophils

Potent bronchoconstrictor Promotes vasoconstriction fewer gastrointestinal (GI) side effects. Highly selective COX-2 inhibitors have been relatively successful with regard to their reduced GI toxicity. However, based on the role of COX-2 derived PGs in normal physiology, there exists the potential for other side effects such as increased cardiovascular events for at-risk patients and aggravated renal impairment in patients with reduced renal function.

Arachidonic Acid


H COX-1/COX-2 Prostaglandin H2


Food Allergies

Food Allergies

Peanuts can leave you breathless. Cat dander can lead to itchy eyes, a stuffy nose, coughing and sneezing. And most of us have suffered through those seasonal allergies with horrible pollen counts. Learn more...

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