Ep1ep4 Ip

BLT1, BLT2 CysLT1, CysLT2

Most cell types

Endothelial cells

Platelets Monocytes Mast cells

Monocytes Macrophages Uterine cells Epithelial cells Neutrophils Monocytes Macrophages Eosinophils Mast cells Eosinophils Mast cells Macrophages Smooth muscle cells

Potent vasodilator

Stimulates bone and cartilage resorption

Increases microvascular permeability

Mediator of febrile responses

Hyperalgesic

Potent vasodilator

Inhibits platelet aggregation

Potent vasoconstrictor and inducer of platelet aggregation Vasodilator

Inhibits platelet aggregation

Potent vasoconstrictor and bronchoconstrictor

Myometrial and smooth muscle cell contraction

Potent neutrophil chemotactic and chemokinetic agent Induces leucocyte adhesion

Induces release of reactive oxygen species and hydrolytic enzymes by neutrophils

Potent bronchoconstrictor Promotes vasoconstriction fewer gastrointestinal (GI) side effects. Highly selective COX-2 inhibitors have been relatively successful with regard to their reduced GI toxicity. However, based on the role of COX-2 derived PGs in normal physiology, there exists the potential for other side effects such as increased cardiovascular events for at-risk patients and aggravated renal impairment in patients with reduced renal function.

Arachidonic Acid

pgg2

H COX-1/COX-2 Prostaglandin H2

V TXA2

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