Excessive Consumption of Vitamin D and Toxic Effects

Because the hormonal form of vitamin D, 1,25DHCC, acts on the DNA in the genome, high intakes or excessive drug dosages of the vitamin lead to synthetic overexpression of proteins that contribute to toxic effects. In recent years, the amounts of vitamin D needed to cause toxic effects has been found to be considerably higher than previously thought; but caution is needed via monitoring of serum 25HCC to ensure that blood concentrations do not get too high. Concern is expressed here that excessive treatment of those with rickets or osteomalacia with high doses of vitamin D may result in toxicity.

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