Extrapolating Data to Other Life Stage and Gender Groups

Invariably, there is not enough information on studied populations to establish reference values directly for each subgroup. Knowledge of nutritional needs as well as response to higher levels of intake and exposure for such groups, such as during pregnancy or preadolescence, would be very useful. In order to provide adequate guidance when data are lacking, reference intakes are routinely provided by extrapolating the available primary data to these important age or life-stage groups from those subgroups for whom data are available. Consensus on the best methods to use for extrapolation when data are lacking, with modeling and consideration of more sophisticated approaches than just body size or caloric expenditure, is needed to enhance the utility of the derived reference values.

Hazard Identification What adverse effects have been described?

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