These two disorders may have overlapping pheno-types. In type IV or familial endogenous hypertrigly-ceridemia, triacylglycerol levels are increased and HDL is usually decreased. This disorder appears to be autosomal dominant and relatively frequent in populations consuming high-fat diets. The precise molecular defect has not been defined; however, the increase in triacylglycerol is associated with overproduction of triacylglycerol by the liver and often with consequent reduced clearance. Diet should be the first step in therapy, followed if necessary by pharmacotherapy using fibrates or nicotinic acid. Premature CHD has been seen in some but not all cases presenting with this phenotype.
Type V hyperlipidemia is a much more rare disorder. Usually the first signs of this abnormality are abdominal pain or pancreatitis. VLDL levels are high and chylomicrons are present in the fasting state. This abnormality has not been linked to any specific molecular defect. Besides the primary genetic defect, other secondary causes of type V hyperlipidemia are poorly controlled diabetes melli-tus, nephrotic syndrome, hypothyroidism, glycogen storage disease, and pregnancy. Recent data indicate increased susceptibility to atherosclerosis.
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All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.