Fatty Acid Activation

Biochemically, fatty acids are rather nonreactive molecules unless they are first activated by thioesteri-fication to coenzyme A (CoA). This reaction is catalyzed by acyl-CoA synthetases (also known as acid : CoA ligases, E.C. 6.2.1.x). The overall acyl-CoA synthetase reaction is

RCOOH + ATP + CoA-SH ! RCO-S-CoA + AMP + PPi where PPi is inorganic pyrophosphate, ATP is ade-nosine triphosphate, and AMP is adenosine monophosphate. Owing to the wide diversity of fatty-acid chain lengths, many enzymes with varied substrate specificities have been identified.

It is estimated that humans have more than 25 enzymes capable of activating fatty acids and/or fatty-acid-like compounds. Acyl-CoA synthetases that activate fatty acids of similar chain lengths often have different tissue-expression patterns and/ or different subcellular locations. Thus, each enzyme may direct its fatty-acid substrates into a particular metabolic pathway.

Was this article helpful?

0 0
30 Day Low Carb Diet Ketosis Plan

30 Day Low Carb Diet Ketosis Plan

An Open Letter To Anyone Who Wants To Lose Up To 20 Pounds In 30 Days The 'Low Carb' Way. 30-Day Low Carb Diet 'Ketosis Plan' has already helped scores of people lose their excess pounds and inches faster and easier than they ever thought possible. Why not find out what 30-Day Low Carb Diet 'Ketosis Plan' can do for you by trying it out for yourself.

Get My Free Ebook


Post a comment