Ffa

Resistin

Proteins extracellular matrix

Osteonectin

Figure 12 Factors secreted by white adipose tissue, which underlie the multifunctional nature of this endocrine organ. Although due to their pleiotropic effects some of the elements might be included in more than one physiological role, they have been included only under one function for simplicity reasons. apoE, apolipoprotein E; ASP, acylation-stimulating protein; CRP, C-reactive protein; CSFs, colony-stimulating factors; FFA, free fatty acids; HGF, hepatocyte growth factor; IGF-1, insulin-like growth factor-1; IL-10, interleukin-10; IL-17 D, interleukin-17 D; IL-1Ra, interleukin-1 receptor antagonist; IL-1,3, interleukin-1,3; IL-6, interleukin, 6; IL-8, interleukin-8; LIF, leukemia inhibitory factor; LPL, lipoprotein lipase; MCP-1, monocyte chemoattractant protein-1; NGF, nerve growth factor; PAI-1, plasminogen activator inhibitor -1; PGF2a, prostaglandin F2a; PGI2, prostacyclin; SAA3, serum amyloid A3; sR, soluble receptor; TGF-,3, transforming growth factor-^; TNF-a, tumor necrosis factor-a; VAP-1/SSAO, vascular adhesion protein-1/semicarbazide-sensitive amine oxidase; VEGF, vascular endothelial growth factor.

Adipsin ASP

Factors B and C3 CSFs IL-17 D SAA3

Growth factors

Retinol

a1-acid glycoprot. VAP-1/SSAO

TGF/3 IGF-1 HGF NGF

Lysophosp hatidic acid

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