Further Reading

Bergstrom S, Danielsson H, Klenberg D, and Samuelsson B (1964) The enzymatic conversion of essential fatty acids into prostaglandins. Journal of Biological Chemistry 239: 4006-4009.

Boers M (2001) NSAIDs and selective COX-2 inhibitors: competition between gastroprotection and cardioprotection. Lancet 357: 1222-1223.

Dyerberg J and Bang HO (1979) Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet 2: 433-435.

Drazen JM, Israel E, and O'Bryne PM (1999) Treatment of asthma with drugs modifying the leukotriene pathway. The New England Journal of Medicine 340: 197-206.

Fitzgerald GA and Patrono C (2001) The coxibs, selective inhibitors of cyclooxygenase-2. The New England Journal of Medicine 345: 433-442.

Funk CD (2001) Prostaglandins and leukotrienes: Advances in eicosanoid biology. Science 294: 1871-1875.

Harris RC and Breyer MD (2001) Physiological regulation of COX-2 in the kidney. American Journal of Physiology 281: F1-11.

James MJ, Gibson RA, and Cleland LG (2000) Dietary poly-unsaturated fatty acids and inflammatory mediator production. American Journal of Clinical Nutrition 71: 343s-348s.

Hui Y and Funk CD (2002) Cysteinyl leukotriene receptors. Biochemical Pharmacology 64: 1549-1557.

McAdam BF, Catella-Lawson F, Mardini IA, Kapoor S, Lawson JA, and Fitzgerald GA (1999) Systemic biosynthesis of prosta-cyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2. Proceedings of the National Academy of Science USA: 96: 272-277.

Narumiya S and FitzGerald GA (2001) Genetic and pharmacological analysis of prostanoid receptor function. The Journal of Clinical Investigation 108: 25-30.

Prescott SM (2000) Is cyclooxygenase-2 the alpha and the omega in cancer? The Journal of Clinical Investigation 105: 15111513.

Samuelsson B, Dahlen SE, Lindgren JA, Rouzer CA, and Serhan CN (1987) Leukotrienes and lipoxins: structures, biosynthesis and biological effects. Science 237: 1171-1176.

Samuelsson B and Funk CD (1989) Enzymes involved in the biosynthesis of leukotriene B4. Journal ofBiological Chemistry 264: 19469-19472.

Serhan CN and Levy B (2003) Success of prostaglandin E2 in structure-function is a challenge for structure-based therapeutics. Proceedings of the National Academy of Science USA 100: 8609-8611.

Smith WL and Lanenbach R (2001) Why there are two cyclo-oxygenase isozymes. The Journal of Clinical Investigation 107: 1491-1495.

Smith WL, DeWitt DL, and Garavito RM (2000) Cyclooxygenase: structural, cellular and molecular biology. Annual Review of Biochemistry 69: 145-182.

Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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