Glucose-dependent insulinotrophic peptide is also known as gastric inhibitory peptide. GIP is the third duodenal peptide hormone now recognized to be the 'incretin' peptide important for the mobilization and attenuation of the insulin response to glucose as it is absorbed from the small intestine. GIP initiates the meal stimulus of the pancreatic islets, heralding the absorptive phase of metabolism. Lipid, carbohydrate, acid, and duodenal distension all serve to promote the secretion of GIP from the duodenal mucosa.

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