H O

Acetate

Acetaldehyde

Figure 2 Chemical structures of acetaldehyde and acetate, the products of ethanol metabolism.

Ethanol Metabolism
Figure 3 Pathways of ethanol metabolism.

products of five gene loci (ADH1-5). Class 1 isoenzymes generally require a low concentration of ethanol to achieve 'half-maximal activity' (low Km), whereas class 2 isoenzymes have a relatively high Km. Class 3 ADH has a low affinity for ethanol and does not participate in the oxidation of ethanol in the liver. Class 4 ADH is found in the human stomach and class 5 has been reported in liver and

Table 5 Classes of alcohol dehydrogenase isoenzymes

Class

Subunit

Location

Km (mmol/lf

Vmax

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