Hn Nh I I

HC-CH O

Bisnorbiotin methyl ketone

Figure 1 Biotin metabolism and degradation. Ovals denote enzymes or enzyme systems; rectangles denote biotin, intermediates, and metabolites. AMP, adenosine monophosphae; ATP, adenosine triphosphate; CoA, coenzyme A; Ppi, pyrophosphate; *, site of attachment of carboxyl moiety.

Table 1 Normal range for biotin and metabolites in human serum and urinea

Compound

Serum

Urine

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