Hyperhomocysteinemia

Under conditions of maximal metabolic efficiency, plasma levels of homocysteine range from 4 to 10 mmoll-1. Metabolic blocks in homocysteine metabolism lead to accumulation of intracellular homocysteine with subsequent export into the blood. Depending on the magnitude of the metabolic impairment, plasma homocysteine levels can rise to varying degrees, as defined in Table 2.

Table 2 Degrees of hyperhomocysteinemia

Total plasma homocysteine

Designation

4-10 mmol r1

Normal

11-25 mmoir1

Mild to moderate

26-50 immoir1

Intermediate

>50 mmol r1

Severe

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