0 10 20 30 40 50 60 Time (minutes)

Figure 4 Glucose levels during an IVGTT in 41 healthy subjects with normal glucose tolerance. Glucose (0.3 g/kg) was injected intravenously at time 0. Linear regression curve for the logarithmic values from minutes 8 to 60. kg value = 1.61 ± 0.08%/min. From Ahren B, unpublished data. Means ± SEM are shown.

Clinical Aspects of IGT Epidemiology of IGT

During the 1980s, studies on the prevalence of IGT and type 2 diabetes were performed in several different populations. It became apparent that the prevalence of these conditions, although high in many populations, varied markedly between different populations. Thus, for some populations, mainly in Africa, data from only a few percent were published, whereas an exceedingly high prevalence (60%) was reported in some populations, such as Pima Indians. Figure 5 shows a collaborative study from 1993 in which data from several populations throughout the world are summarized. Studies during the past 10 years have further increased our knowledge since they have included additional populations and demonstrated that the

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