Info

No No Yes

No No No Yes

aUnaffected women were those without a neural tube defect pregnancy either before or during the particular study, except for Wald et al. (1996), in which women had at least one neural tube defect pregnancy before the study. "Median value.

From Wald NJ, Hackshaw AK, Stone R and Sourial NA (1996) Blood folic acid and vitamin B12 in relation to neural tube defects. British Journal of Obstetrics and Gynaecology 103: 319-324, Blackwell Scientific.

Table 4 Red cell folate (RCF) and central nervous system defects

Study

No. of pregnancies

Difference

Statistical significance

Blood taken at antenatal booking Kirke et al. (1993)

Blood taken in first trimester

Smithells et al. (1976)

All women (antenatal booking and first trimester)

Blood taken in second trimester

Laurence et al. (1981)

Economides et al. (1992) All women (second trimester)

Blood taken after delivery

Yates etal. (1987)

Bower and Stanley (1989)

Wild etal. (1993)

All women (after delivery)

Affected Unaffecteda

Affected Unaffected Affected Unaffected

Affected Unaffected Affected Unaffected

Affected

Unaffected

Affected

Unaffected

Affected

Unaffected

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