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aSix NTD pregnancies in 593 women supplemented with folic acid and 21 NTD pregnancies in 602 women not supplemented with folic acid. Statistically significant difference in NTD rate between supplemented and nonsupplemented groups.

aSix NTD pregnancies in 593 women supplemented with folic acid and 21 NTD pregnancies in 602 women not supplemented with folic acid. Statistically significant difference in NTD rate between supplemented and nonsupplemented groups.

Table 2 Main observational studies of the effect of periconceptional use of folic acid supplements on NTD riska

Study

Odds ratio

Mulinare et al. (1988)

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