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allows the separation of several triacylglycerol-rich lipoproteins subfractions.

Lipoproteins containing apo A-I can be separated into two major species: those containing both apo A-I and apo A-II, known as LpAI:AII, and those containing apo A-I but not apo A-II (LpAI). Small numbers of particles containing apo A-II, but not apo A-I, have been detected in normal subjects; however, these particles could become predominant in the presence of rare genetic disorders associated with HDL deficiency. Another HDL species containing apo A-I and apo E is important in reverse cholesterol transport by transporting cholesterol from the cell membranes to the liver for elimination from the body.

Lipoproteins containing apo B consist of four lipoprotein families. Lipoproteins containing apo B only (Lp(B)) are cholesteryl ester-rich and are found primarily within the LDL density range, but they have also been detected within the VLDL range. Particles containing both apo B and apo C (LpB:C), apo B and apo E (LpB:E), and all three apolipoprotein groups (LpB:E:C), are triacylgly-cerol-rich and are found within the VLDL and IDL density range. The apo C and apo E content decreases as density increases.

More recently, the affinity for lectins of Lp(a), a lipoprotein containing apo B-100 as well as an anti-genically unique apolipoprotein [apo(a)], has been used to develop a new technique to measure the levels of this lipoprotein in plasma.

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